食品伙伴網(wǎng)報道，據(jù)美國營養(yǎng)成分網(wǎng)8月9日消息稱,一項來自于動物試驗及初步人體試驗的研究數(shù)據(jù)表明，每天攝入來源于柑橘的黃酮及檸檬苦素類似物可降低患糖尿病的風險。這一研究結(jié)果發(fā)表在功能性食品雜志（ Journal of Functional Foods）上。
圖片來源：greenprophet.com
來自加拿大安大略省的研究團隊對此課題進行了研究。在美國估計有2400萬名糖尿病患者，相當于美國人口的8%。根據(jù)美國糖尿病協(xié)會2005-2007年的統(tǒng)計數(shù)字，花費在這一疾病治療上的金額為1240億美元，而其中1160億美元花費在藥物治療上。
研究人員進行了2項研究，其中一項的是試驗對象是倉鼠，另一項的試驗對象為19名空腹血糖值不正常的糖尿病患者。
動物試驗中，研究人員把18只雄性倉鼠分為三組，第一組喂養(yǎng)正常的食物，第二組的飲食中60%為果糖，第三組的飲食中60%為果糖及1%的柑橘提取物補充劑。結(jié)果表明，與僅添加果糖的倉鼠相比，添加了柑橘提取物的倉鼠表現(xiàn)出血糖水平、胰島素水平及總膽固醇量、甘油三酯量的下降；并且沒有任何不良反應的記錄。
而在人體的初步試驗中，受試人員被隨機分組，一組服用安慰劑作對照，一組服用柑橘提取物，每天的劑量均為1050mg，連續(xù)服用84天。實驗結(jié)果為，總膽固醇量及低密度脂蛋白的量同比下降13%和23%。并且同時發(fā)現(xiàn)糖耐量升高。
食品伙伴網(wǎng)編者注：
何為糖耐量？
正常人在進食米、面主食或服葡萄糖后，幾乎全被腸道吸收，使血糖升高，刺激胰島素分泌、肝糖元合成增加，分解受抑制，肝糖輸出減少，體內(nèi)組織對葡萄糖利用增加，因此飯后最高血糖不超過10.0mmol/L，且進食或多或少血糖都保持在一個比較穩(wěn)定的范圍內(nèi)。這說明正常人對葡萄糖有很強的耐受能力，即葡萄糖耐量正常。但若胰島素分泌不足的人，口服 75g葡萄糖后2小時可超過7.8mmol/L，可等于或大于11.1mmol/L，說明此人對葡萄糖耐量已降低。
----- 源自互動百科
原文報道：
Citrus extract shows benefits for diabetics: Study
By Stephen Daniells, 09-Aug-2010
Daily supplements of citrus-derived flavanoids and limonoids may reduce risk factors for diabetes like glucose tolerance, suggests data from an animal and pilot study with humans.
The branded Diabetinol ingredient produced significant reductions in glucose intolerance, total cholesterol, and LDL-cholesterol levels, according to findings published in the Journal of Functional Foods.
“These data suggest that Diabetinol as a natural food product may have a protective effect in individuals with a combined impaired fasting glucose and hyperlipidemia,” wrote the researchers, led by Malkanthi Evans from Ontario, Canada-based KGK Synergize.
Diabetes affects an estimated 24 million Americans, equal to 8 percent of the population. The total costs are thought to be as much as $174 billion, with $116 billion being direct costs from medication, according to 2005-2007 American Diabetes Association figures.
Study details
The researchers performed two studies – one with hamsters, and the other a pilot study with 19 people with impaired fasting glucose.
The hamster study involved 18 male animals divided into three groups: One group consumed regular chow, the second group was fed with 60 percent fructose, and the third group received the 60 percent fructose group supplemented with 1 percent Diabetinol.
Compared to the hamsters fed only the fructose, the citrus extract-supplemented group demonstrated a decrease in blood glucose, insulin, total cholesterol and triacylglycerol levels, said the researchers. Furthermore, no adverse events were recorded.
The human randomized, placebo-controlled, double-blind study, conducted by Florida-based SIBR Research Inc., involved 19 people with impaired fasting glucose. The subjects, who were all receiving oral medication, were assigned to receive a daily 1050 milligram dose of the citrus extract or placebo for 84 days.
At the end of the study the researchers noted significant improvements in total and LDL cholesterol levels of 13 and 23 percent, respectively. Furthermore, a reduction in glucose intolerance was observed, said the researchers.
The researchers confirmed that study was ongoing in this area with an “additional six-month study is underway to evaluate Diabetinol treatment in a larger sample of subjects with type-II diabetes”.
原文地址：http://www.nutraingredients-usa.com/Research/Citrus-extract-shows-benefits-for-diabetics-Study
日期：2010-08-10
